IODINE IN THE HORSE
TOO MUCH OR TOO LITTLE

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Iodine is an essential nutrient for reproduction and normal physiological function in the horse. Thyroxine contains iodine, and this hormone along with triiodothyronine (T3) has powerful effects on the overall health of the horse.  These hormones influence nearly every process in the body, from heat regulation and feed utilization to proper bone growth and maturation.
  
Iodine Deficiency
Nearly 75% of the iodine in an animal's body is in the thyroid gland.  Iodine deficiency may result in goiter as the thyroid gland enlarges in an attempt to produce thyroxine.  In the horse, goiters often occur in the foal at birth.  Foal goiter may result from a deficiency in iodine in the mare's ration during pregnancy or it may be caused by a goitrogenic substance.  Symptoms of iodine deficiency may be a stillborn foal or a very weak foal at birth that cannot stand and nurse.  The foal may also have a rough haircoat, contracted tendons, angular limb deformities or other abnormal bone development.  A Russian study (Kruzkova, 1968) indicated that mares which had shown anovulatory cycles responded to iodine supplementation.

Iodine Toxicity 
While iodine deficiency is the primary cause of goiter in foals, excessive levels of iodine may also cause this condition.  The maximal tolerable dietary concentration of iodine has been estimated to be 5 mg/kg (PPM) of dry matter (NRC,1980), equivalent to 50 mg of iodine/day for a horse consuming 10 kg of dry matter daily. 

The horses most sensitive to high iodine levels are foals from mares who are supplemented with high levels of iodine.  Iodine is concentrated across the placenta and in milk so that the fetus and nursing foal receive much higher concentrations than are present in the mare's ration.  Therefore, goiters may be present in newborn foals while sparing the mother   A dietary intake of 83 mg I/day is the lowest level reported to have caused goiter in a horse more mature than a suckling foal (Drew et al, 1975).  Baker and Lindsey (1968) reported that goitrous foals were born on three farms which were feeding mares high levels of iodine.  The incidence of goiter was proportional to the level of iodine fed and equaled 3% on one farm feeding 48-55 mg I/day, 10% on a farm feeding 56-69 mg I/day and 50% on another farm feeding 288-432 mg I/day.  A neighboring farm which did not have any goitrous foals fed iodine at a rate of 6.3-7 mg I/day. 

Sipple (1969) reviewed a case in which 11% of the foals born on a farm had goiters. Analysis of the diet revealed that the mares received between 160-400 mg I/day. Coincidentally, the author discovered that the manager of this farm was the brother of the manager of one of the farms in Baker's study in Florida. apparently, the Florida horseman had prescribed the same iodine supplement for his brother's horses 1,000 miles away. Drew et al (1975) reported that on one stud farm in England...

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iodine_chart.gif (4247 bytes)

A: 6-7 mg I/day. No suggestion of iodine toxicity in mares or foals. Baker and Lindsey (1968).
B: 9 mg I/day. Level of iodine supplied from SOURCE®.
C: 12-14 mg. I/day. No suggestion of iodine toxicity in mares or foals. Drew et al (1975).
D: 83 mg I/day. Lowest reported level of dietary iodine shown to cause goiter in a horse more mature than a
suckling. Drew et al (1975).
E: 48-55 mg I/day. Goiters in 3% of foals. Baker and Lindsey (1968).
F: 56-69 mg I/day. Goiters in 10% of foals. Baker and Lindsey (1968).
G: 160-400 mg I/day. Goiters in 11% of foals. Sipple (1969).
H: 288-432 mg I/day. Goiters in 50% of foals. Baker and Lindsey(1968).

"IODINE IN THE HORSE
TOO MUCH OR TOO LITTLE"

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